This paper makes the case for smart policy development in Central, Eastern and South-Eastern Europe (CESEE). It uses EIB Investment Survey (EIBIS) 2017 results for CESEE cities to outline local infrastructure gaps and demonstrate the productivity and innovation gaps between CESEE cities and other EU cities. It discusses negative demographic trends in Central, Eastern and South-Eastern Europe, and evaluates capital and non-capital regional convergence in CESEE countries. Introducing a Smart Region Index, to allow the identification of gaps in CESEE regions compared with the EU, it also uses EIBIS to provide further conclusions on obstacles to investment for CESEE municipalities and highlights the importance of the use of EU funds.